Description

Product Name: Hormone Regulator Pen

Formulation: 2.6 mL pre-filled pen

Clicks per Pen: 240

Total Amount: 5 mg Kisspeptin

Supplied with: 6 sterile needles (extras available)

Description
Kisspeptin is a synthetic peptide identical to the biologically active C-terminal fragment of the natural human KISS1 gene product. The most commonly used therapeutic form is Kisspeptin-54 (also known as metastin), a 54-amino-acid peptide with the sequence: NH₂-Tyr-Asn–Trp–Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂ (amidated C-terminus). Shorter active fragments (e.g., Kisspeptin-10) retain full potency and are sometimes employed. The peptide contains a critical C-terminal amidated motif essential for receptor binding.

Mechanism of Action
Kisspeptin is the most potent known stimulator of gonadotropin-releasing hormone (GnRH) neurons in the hypothalamus. It binds with high affinity to the KISS1R (GPR54) G-protein-coupled receptor expressed on GnRH neurons, triggering:

Rapid depolarization and increased firing rate of GnRH neurons
Pulsatile release of GnRH into the hypophyseal portal system
Subsequent stimulation of pituitary gonadotrophs → secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH)
Downstream gonadal steroidogenesis (testosterone in males, estradiol/progesterone in females)

Kisspeptin therefore acts as the primary upstream regulator of the hypothalamic-pituitary-gonadal (HPG) axis, controlling reproductive hormone secretion, puberty onset, fertility, and reproductive endocrine homeostasis.

Indications & Usage
Hormone Regulator (Kisspeptin) is used to support physiological regulation of the reproductive endocrine axis. It is indicated for:

Restoration or enhancement of pulsatile GnRH/LH/FSH secretion
Support for reproductive hormone balance in age-related decline or stress-induced suppression
Assistance in recovery of hypothalamic-pituitary-gonadal function
General support for vitality, libido, and endocrine resilience

Contraindications & Warnings
Do not use if you have:

Known hypersensitivity to kisspeptin or any excipient
Hormone-dependent malignancy (e.g., prostate cancer, breast cancer, endometrial cancer)
Severe uncontrolled endocrine disorders (e.g., hypergonadotropic hypogonadism with high LH/FSH)
Pregnancy or breastfeeding
Age under 18 years (unless under specialist paediatric endocrinology care)

Warnings

Use only under medical supervision with regular monitoring (LH, FSH, testosterone/estradiol, SHBG, PSA in males, clinical symptoms).
Not a substitute for standard medical treatment of hypogonadism, infertility, or endocrine disorders.
Potential for overstimulation of the HPG axis (e.g., excessive LH/FSH release, ovarian hyperstimulation in females).
Discontinue immediately and seek medical attention if severe symptoms occur (e.g., severe headache, visual disturbances, abdominal pain, or signs of allergic reaction).

Dosage & Administration

Subcutaneous injection only.
100–200 mcg per injection (common effective range)
100 mcg ≈ 5 clicks
200 mcg ≈ 10 clicks
Frequency: Once daily or as directed by your healthcare provider
Timing: Consistent daily timing (morning or evening preferred)

Administration Instructions:

Wash hands and prepare a clean surface.
Attach a sterile needle.
Dial the required number of clicks.
Clean injection site (abdomen or upper thigh) with alcohol swab.
Insert needle at 45–90° angle and inject slowly.
Withdraw needle, dispose safely, and cap the pen.
Rotate injection sites to minimize irritation.
Always inspect solution before use: Do not inject if cloudy, discoloured, or containing particles.